Buffalo is located at 42°53'11" North, 78°52'41" West (42.886389, -78.878333).
According to the United States Census Bureau, the city has a total area of 52.51 mi2 (136.01 km2). 40.61 mi2 (105.19 km2) of it is land and 11.90 mi2 (30.82 km2) of it is covered by water. The total area is 22.66% water.
Buffalo is located in the Eastern Standard Time (EST) timezone, GMT-05:00. It observes Daylight Saving Time (DST).