Durham is located at 35°59'36" North, 78°53'54" West (35.993611, -78.898611).
According to the United States Census Bureau, the city has a total area of 94.92 mi2 (245.83 km2). 94.63 mi2 (245.10 km2) of it is land and 0.28 mi2 (0.73 km2) of it is covered by water. The total area is 0.30% water.
Durham is located in the Eastern Standard Time (EST) timezone, GMT-05:00. It observes Daylight Saving Time (DST).