Middletown is located at 40°46'24" North, 82°47'30" West (40.773611, -82.791944).
According to the United States Census Bureau, the city has a total area of 25.80 mi2 (66.82 km2). 25.66 mi2 (66.45 km2) of it is land and 0.14 mi2 (0.37 km2) of it is covered by water. The total area is 0.56% water.
Middletown is located in the Eastern Standard Time (EST) timezone, GMT-05:00. It observes Daylight Saving Time (DST).