Cayce is located at 33°57'56" North, 81°4'26" West (33.965556, -81.073889).
According to the United States Census Bureau, the city has a total area of 11.26 mi2 (29.16 km2). 10.90 mi2 (28.23 km2) of it is land and 0.36 mi2 (0.93 km2) of it is covered by water. The total area is 3.18% water.
Cayce is located in the Eastern Standard Time (EST) timezone, GMT-05:00. It observes Daylight Saving Time (DST).