Mount Pleasant is located at 32°47'36" North, 79°51'44" West (32.793611, -79.862500).
According to the United States Census Bureau, the town has a total area of 49.54 mi2 (128.30 km2). 41.89 mi2 (108.50 km2) of it is land and 7.65 mi2 (19.81 km2) of it is covered by water. The total area is 15.44% water.
Mount Pleasant is located in the Eastern Standard Time (EST) timezone, GMT-05:00. It observes Daylight Saving Time (DST).